The Software Integration Research Thrust is responsible for the overall design, implementation, integration, and deployment of the AIDE-QC holistic quantum-classical software stack. This Thrust interacts with the other Thrusts to influence design decisions, collaborate on concrete workflow component implementations, and ensure high-level usability of the infrastructure for relevant domain-specific scientific computing tasks. The stack design, implementation, and delivery should enable high-level quantum-classical programming, quantum compilation and translation, and backend execution on physical QPUs as well as scalable simulation technologies.